EFFICACY OF INTRAVENOUS IMMUNOGLOBULINS IN RH INCOMPATIBLE NEONATES

BACKGROUND
 This hemolytic disease of fetus and newborn is a condition in which there immunologic hemolysis fetal / neonatal red blood cells.
 OBJECTIVE: 
 To compare the efficacy intravenous immunoglobulins reducing need for exchange transfusion Rh incompatible neonates.
 MATERIALS AND METHOD: Randomized Controlled Trial was conducted from 1st September 2021 to 31st August 2022 at Department Pediatric Medicine, Khyber Teaching Hospital, Peshawar. A total 92 neonates having bilirubin more than 8mg/dl were included study. Randomization performed through lottery method. All received conventional intensive phototherapy given by air shield Ohmeda lamps with white light an intensity 22 μW/cm/nm plus blue 32 μW/cm/nm. Extra fluids (10 mL per kg) administered during session. Subjects group IVIG single dose(1 gm/kg). In B saline instead IVIG. change 1mg considered effective after 4 hours starting treatment. Data recorded efficacy.
 RESULTS: Mean age Group 15.369± 4.98 days while 17.782± 3.31 B. gestational birth 37.608±1.58 weeks 38.173±1.71 parity 3.534±0.28 3.387±0.36 hospital stay 3.2±1.5days 5.7±1.2 A, seen 38 (82.6%) patients as 26 (56.5%) B, resulting significant reduction transfusions, duration session (P=0.006).
 CONCLUSION: It concluded that administration hyperbilirubinemia caused requirement ,decreased time treatment thus safe